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In some cases, it may be appropriate to reintroduce or combine oral medications like PDE5 inhibitors alongside injections for a synergistic effect

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One prevailing theory is that tirzepatide is an imbalanced and biased GLP-1 RA with very low efficacy for recruitment of -arrestin, whilst is acting as an unbiased GIP agonist with full efficacy for -arrestin recruitment [51, 52]

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