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Hyperglycemia-driven insulin signaling defects promote parkinson's disease-like pathology in mice

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The K D values of the His-TRAF6 310-522 interaction with GST-CD40 and GST-RANK were 17.1 2.9 nM and 7.7 nM 1.2 nM, respectively, in contrast to 73.2 13.0 nM with GST-LMP1, as determined by the AlphaScreen PPI assay

10.1161/CIRCRESAHA.121.318866 73 LiuL.FengD.ChenG.ChenM.ZhengQ.SongP.et al (2012)

The translation of findings from rodent models to humans is also often limited by inherent differences in BA metabolism and gut microbiota (147, 163), necessitating rigorous validation in human studies

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