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Thus, metformin may be beneficial by providing mild inhibition of complex I, because the reduced ATP/ADP ratio activates the AMPK signaling pathway, thereby promoting autophagy-mediated degradation of misfolded proteins and dysfunctional organelles [157]

Chemotherapy has been described to deplete the ovarian reserve through both direct toxicity to oocytes (Nguyen et al, 2019), granulosa cell apoptosis (Lopes et al, 2020