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Upon activation, free radicals such as nitric oxide (NO) and superoxide are released, which elevates oxidative stress contributing to pathogen elimination and local tissue damage ( Migraine Pathogenesis: Role of Oxidative Stress, Neuroinflammation, and Mitochondrial Dysfunction Migraine is defined as a neurovascular disorder involving cortical spreading depression (CSD), neurogenic inflammation, and dysfunction in cranial vascular contractility ( Oxidative Stress Oxidative stress role in migraine pathogenesis is emphasized by multiple studies

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Wang S, Yan Y, Xu WJ, Gong SG, Zhong XJ, An QY, et al

Mol Aspects Med 32(46):305315 Ramrez-Rodrguez G, Klempin F, Babu H, Bentez-King G, Kempermann G (2009) Melatonin modulates cell survival of new neurons in the hippocampus of adult mice

493:416 Lim, H et al (2013) JBC