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Emerging approaches involving biomarker panels and multi-omics technologies (such as proteomics and miRNA expression profiling) offer promising avenues for improving diagnostic accuracy

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Mechanistic investigations have implicated oxidative stress, inflammatory responses, and apoptosis as critical components in the etiology of CP-induced POF, although the exact process by which this ovarian toxicity occurs remains unclear

These beneficial effects are consistent with the actions of HIF-1 in cardiomyocytes, which include the reactivation of angiogenesis, a shift toward anaerobic metabolism, and a reduction in apoptosis [91]

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