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Other transcription factors such as GSK-3, p38-MAPK, ERK, Akt, JNK, and phosphoinositide-3-kinase (PI3K)/Akt have also been reported to mediate the neuroprotective effects of nootropic foods via their downstream factors like p53, Bax, or Bcl2 [56, 79, 83, 86,87,88] (Fig