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Suicide completion samples were mostly enriched in the endocannabinoid and apoptotic pathways (CAPNS1, CSNK2B, PTP4A2)

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Furthermore, in STZ-induced T2DM model rats, JUN protein expression was increased, and NRF2 expression was decreased in pancreatic tissues, potentially linking these changes to ferroptosis in T2DM-related -cell dysfunction [72]

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In clinical practice, weighing the therapeutic benefits against the potential adverse effects is crucial in individualizing treatment approaches for patients with PD