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Currently, several drugs with fast track designation are being tested in phase III clinical trials, and many other drugs have moved into phase II clinical trials

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Physiologically, ROS and RNS are detoxified by enzymatic systems such as catalase, thioredoxin, and superoxide dismutase [38]

Peer-reviewed publications and reference materials

10.1016/j.actbio.2018.07.008 190 MoskowitzR

The study revealed that, in the presence of mutant HTT, a significant portion of genes with altered expression exhibited pronounced changes in DNA methylation, particularly in regions with low CpG content known to undergo methylation changes due to neuronal activity