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Different approaches have been followed to protect islet grafts from detrimental IBMIR, including inhibiting coagulation, complement activation, and leukocyte recruitment (16)

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Int J Biol Macromol 119:741746 Heise T, Nosek L, Rnn BB, Endahl L, Heinemann L, Kapitza C, Draeger E (2004) Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes

Bioreducible exosomes encapsulating glycolysis inhibitors potentiate mitochondria-targeted sonodynamic cancer therapy via cancer-targeted drug release and cellular energy depletion