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Fewtrell and Gomperts [40] offered the first evidence in 1977, when the authors observed quercetins direct inhibitory effect on the release of histamine from mast cells, demonstrating its effect on Ca 2+ flux

However, recent studies have shown that in the tumor microenvironment, cancer cells are the dominant players in glutamine metabolism [99]

Activation of MLCK leads to cytoskeletal contraction, disrupting the integrity of TJs

is used in traditional Chinese medicine for the treatment of cerebrovascular and cardiovascular diseases (Wang et al., 2014)

We then used our pMHC complex structural modelling software RosettaMHC 36 to model the structure of peptide complexes encompassing additional HLA alleles