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1), thirteen of which are generated enzymatically (e.g., N 6 -methyladenosine (m 6 A), , dihydrouridine, N 4 -acetylcytidine (ac 4 C), N 1 -methyladenosine (m 1 A), N 7 -methylguanosine (m 7 G), 2O-methyl modifications (2O-Me/Nm: Cm, Am, Gm, Um), 5-methylcytidine (m 5 C), 5-hydroxymethylcytidine (hm 5 C), and inosine (I))

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