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J Med Chem2026 Mar 12;69(5):5501-5539

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Dahiya, D., & Nigam, P

Furthermore, significantly elevated branch-chain fatty acids (BCFA), which are metabolic products of protein breakdown have been hypothesized to induce epithelium inflammation (Aguirre et al., 2016)

In aging, oligodendrocytes and OPCs also accumulate signs of oxidative DNA (mitochondrial and nuclear) damage, a feature which is commonly found in neurodegenerative diseases like Alzheimers disease and MS (Tse and Herrup, 2017)