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Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints

HaloTag Protein Tag Protein fusion tags are used to aid expression of suitable levels of soluble protein as well as purification

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These are usually performed in parallel or before formulation-device performance testing, such as assays of active and excipients (Table 2)

Since the host-derived damage-associated molecular patterns (DAMPs), like bile acids, can directly engage GSDME to trigger pyroptosis, we reasoned that there might have certain endogenous metabolites capable of inhibiting GSDME activation