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Cellular mechanisms that exist to counteract ROS include stabilization by enzymes such as superoxide dismutase and catalase, and direct scavenging by antioxidant molecules such as glutathione (GSH), a major intracellular antioxidant

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A supplement strategy should not overlook: Adequate total protein Cysteine-containing foods such as poultry, eggs, dairy, legumes and meat Glycine from protein-rich foods, collagen and connective tissues Selenium from seafood, eggs, meat and selected plant foods Magnesium and B-vitamin adequacy Cruciferous vegetables and other foods that support endogenous antioxidant-response pathways Food does not always replace clinically appropriate supplementation, but poor protein and nutrient intake can undermine the pathway a supplement is intended to support

Figure 8: Kaplan-Meier Curves for Overall Survival in PARAMOUNT Treatment of Recurrent Disease After Prior Chemotherapy The efficacy of pemetrexed for injection was evaluated in Study JMEI (NCT00004881), a multicenter, randomized (1:1), open-label study conducted in patients with Stage III or IV NSCLC that had recurred or progressed following one prior chemotherapy regimen for advanced disease