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Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target

This is the second messenger system that leads to PKC activation and calcium mobilization

Kim et al., 2016

Malic enzymes in mammals are classified into three isoforms, ME1, ME2, and ME3, based on their subcellular localization and cofactor specificity, with each serving a distinct physiological function