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Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways

An Activation Likelihood Estimation meta-analysis revealed that patients with VCI consistently exhibit reduced ALFF and diminished FC at key nodes of the default mode network, specifically the precuneus and cingulate gyrus

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Vegetarian, zero sugar, zero calories, gluten free, non-GMO

Leggio et al., 2016)

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy