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Case-finding using a direct question about gambling in patients at increased risk is recommended

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(2015), based on 15 years of clinical observation, concluded that frequent, high-dose administrations of vitamin B12 injections, in combination with oral folic acid, may respond favorably in alleviating the profound fatigue and cognitive dysfunction seen in ME/CFS patients

Baseline and periodic blood pressure measurements, particularly in patients with cardiovascular disease or those taking cardiovascular medications, would identify any clinically significant hemodynamic effects