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C.LoTempioJ.AyanyanS.CarrieJ.et al (2019)

Porcinederived collagen peptides promote reepithelialisation through activation of integrin signalling[J]

doi: 10.3389/fvets.2025.1558440 Received 13 January 2025 Accepted 05 May 2025 Published 05 June 2025 Volume 12 - 2025 Edited by Moyosore Joseph Adegbeye, University of Africa, Nigeria Reviewed by Can Yang, Hengyang Normal University, China Fuquan Yin, Guangdong Ocean University, China Updates Copyright 2025 Qu, Sun, Liang, Nie, Gao, Yuan, Wang and Zhou

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This signaling not only upregulates anti-apoptotic proteins such as Bcl-2 but also stimulates the secretion of IL-6, reinforcing an autocrine and paracrine loop that sustains inflammation and tumor growth [126]

Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018