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Efforts are underway to establish standardized reference ranges for creatine in saliva, blood, and tissue compartments, incorporating adjustments for age, sex, and physiological status to enhance clinical interpretability [55]

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Adversely, iGluR antagonists CNQX, DNQX, and DL-2-amino-5-phosphonopentanoic acid (AP-5) show an inhibitory effect on Ca 2+ signaling and pollen tube growth ( AtGLR1.2 and AtGLR3.7 mutants can weaken Ca 2+ signaling in pollen tube, the AtGLR1.2 mutants show abnormally deformed tips and tubes, while the AtGLR3.7 mutant tubes grow slower than wild-type ( In addition, GLRs not only are activated by amino acids (Glu