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These SPIONs, such as mannose-coated SPIONs, have been extensively explored in pain models for their CAT- and POD-like activities, and their ability to modulate oxidative stress may contribute to therapeutic effects beyond hyperthermia [132]

The activation of HSPB1 by protein kinase C decreased ferroptosis by lowering iron-mediated generation of lipid reactive oxygen species

One such key protein is ZnT8, which is essential for the crystallization, processing, storage, and secretion of insulin, as well as the overall metabolism of glucose [67]

AngII has been shown to activate AT1Rs, inducing mitochondrial dysfunction and oxidative stress in hepatocytes through the downregulation of antioxidant enzymes (SOD2 and GPx1) and elevated pro-inflammatory mediators (TNF-, monocyte chemoattractant protein 1 and IL-8) (21), and these effects may negatively impact cell membrane sodium/water retention and the development of pathological changes such as cytoplasmic vacuolization and hepatocyte edema

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Croy I, Nordin S, Hummel T

Preferential redox regulation of cysteine-based protein tyrosine phosphatases: structural and biochemical diversity