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Instead of targeting blood flow, PT-141 targets receptors in the brain linked to sexual arousal creating a pathway for increased desire and satisfaction at the source

References National Center for Biotechnology Information (2021)

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Therefore, men on important oral meds (like certain diabetes drugs, blood thinners, etc.) should separate their dosing from PT-141 by a couple of hours and monitor those medications effectiveness

Genital tissue, for instance, has about 50% more melanocytes per unit of area than does truncal skin

Mature melanin-containing melanosomes are transported from a perinuclear position in the cytoplasm of the melanocytes into and along microtubules towards the end of the dendritic processes, borne by the motor proteins kinesin and dynein