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Lactate secreted by CRC cells promotes the polarization of TAMs toward an M2-like immunosuppressive phenotype, impairs CD8 T cell function, and reduces the efficacy of ICIs [126]

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Vitamin A (vitA) deficiency has also been associated with incident TB and correlated with increased mortality in HIV/TB co-infected individuals

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LovegroveJJacksonKKaimilaYLignouSLovegroveANortonVet al

doi:10.2174/0109298673251025230919105818