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In T2D patients (n = 25, age 2565), consumption of 1 g L-citrulline twice a day for 4 weeks reduces the T2D-induced increase in arginase activity and increases plasma nitrites, effects corroborated by improvement of ACh-induced relaxation in ex vivo mouse aortic rings incubated (24-h) in low or high glucose-containing media and increases in NO production in ECs treated with high glucose (Shatanawi et al., 2020)

When it is compromised, skin becomes more vulnerable to bacteria, pollution, allergens, and UV damage

Oxidative stress can impair aquaporin function, reducing the efficiency of cellular water uptake and retention

Acknowledgements The study is supported by a Singapore EDB-IPP grant (grant number: RL2012035)

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Comparison of ionic liquids and chemical permeation enhancers for transdermal drug delivery