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From our point of view, therapeutic options must not only be directed to reach a molecular target, which ultimately would represent a fixed picture of the disease, but also to restore physiological global context in terms of nitro-oxidative stress and inflammatory response, just as the antioxidant treatment seems to act

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J Am Coll Cardiol 38: 307-314, 2001 Yamamoto M, Hara H, Adechi T: Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface

GSH Glutathione, GSSG Glutathione disulfide 1 Values are expressed as nmol/g of fresh tissue for GSH, GSSG and total glutathione or as mol/mol for GSSG/GSH ratios

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Saitama, Japan)