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Energy & Metabolism As an essential B-vitamin, B12 supports energy production at the cellular level and helps maintain a healthy metabolism

About 1 in 10 people aged 55 years and over are affected by PN, and the most common cause is diabetes

In these cases, your doctor may request additional tests to assess functional B12 status: Methylmalonic acid (MMA) : Elevated levels suggest tissue B12 deficiency, as B12 is required to metabolise MMA (note that renal impairment can also raise MMA levels) Homocysteine : Raised homocysteine can indicate B12 or folate deficiency (also affected by renal function) Holotranscobalamin (active B12) : Measures the biologically active fraction of B12 [4] [8] Full blood count : May reveal macrocytic anaemia (enlarged red blood cells) characteristic of B12 deficiency If B12 deficiency is confirmed, your doctor will likely investigate the cause with tests such as intrinsic factor antibodies (and sometimes parietal cell antibodies) to check for pernicious anaemia, or coeliac serology if malabsorption is suspected

Here are the most common ones and how to ensure you don't fall into the same traps

PPAR is a nuclear receptor involved in fat oxidation, energy expenditure, and mitochondrial function

Medication Interference : Some drugs, such as metformin, used for the treatment of Diabetic patients, and Proton-pump inhibitors, which treat patients with Acid reflux, prevent B12 absorption