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Understanding these sources of oxidative stress is essential for developing targeted therapeutic interventions, including antioxidant supplementation, anti-inflammatory treatments, and lifestyle modifications, to improve sperm function and enhance male fertility (95)

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Altogether, the DHODH/CoQH2 axis as well as the GCH1/BH4 axis are both GPX4-independent regulatory systems of ferroptosis, localized within the mitochondria and the cytosol, respectively

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It was first approved as Egrifta in November 2010 for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, and it remains a prescription drug with a regulator-reviewed label, including a defined dose, defined contraindications, and required safety monitoring