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The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

Carvalho MMF, Reis LLT, Lopes JMM et al (2018) Aai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose

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That NADH is then shuttled to the mitochondrial membrane

2015) and contributes to glioma progression via several pathways, such as the cell cycle pathway (Yao et al

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