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Nevertheless, it is worth to notice that neither everolimus nor temsirolimus seem to be selective for all cancer cell lines as EGCG, resveratrol or curcumin (209)

Key transcription factors regulating the expression and induction of GCLC by pro- and anti-oxidants include nuclear respiratory factor NRF2/NRF1, activator protein-1 (AP-1), and nuclear factor kappa B (NFB)