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De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

30 mice were fasted for 12 h and then intraperitoneally injected with STZ (50 mg/kg) for five days to establish diabetic mice

The combination of N-terminal amine, histidine at position 2, and intervening amide nitrogen is a recurrent high-affinity copper-binding motif in peptide biochemistry the same general motif also appears in human serum albumin's N-terminal copper-binding site