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There is also emerging evidence that lactate influences immune-cell behavior through lactylation-dependent mechanisms, offering an additional route by which these metabolically stressed niches stabilize inflammatory phenotypes and impede regulatory recovery [136, 137]

Multiomics Analysis Including the Oxidative Stress-Associated Metabolites In order to construct a second giant network including proteins interconnecting with the metabolites, we entered the latter in OmicsNet analysis and examined the MPIs (using the KEGG and IntAct and using only the first-order MPIs)