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J., Ma, Q

Science 2018, 360 (6387), 436439

10.1073/pnas.171300598 Proc

In animal models of HD, atrophic astrocytes in striatum retract their leaflets from cortico-striatal synapses, which are known to be affected in the early HD

The target genes encompass those that encode proteins related to angiogenesis (e.g., Vascular Endothelial Growth Factor (VEGF)), glycolysis (e.g., GLUTs, glycolytic enzymes), tumor survival (e.g., Bcl-2), metastasis, and other factors facilitating adaptation to hypoxia [26]