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Thus, it is possible that the combination of low GH and normal IGF-I serves as a physiological mechanism aimed at preserving the GH/IGF-I anabolic effects and minimizing the insulin-antagonistic effects of GH without compromising the positive IGF-I metabolic effects

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The underlying molecular mechanisms involve direct ROS-induced oxidative damage to neuronal lipids, proteins and DNA [331], as well as ROS-mediated oxidative modifications that crucially promote the aberrant aggregation of toxic proteins [332]

218,219 9 The Consequences of Untreated Hearing Loss The ability to convert mechanical sound waves into electrical signals that travel to and are interpreted in the brain is a vital function, and hearing loss can lead to several important neurological changes