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10.1016/j.sajb.2011.08.005 31 FaizeM.BurgosL.FaizeL.PiquerasA.NicolasE.Barba-EspinG.et al

Moreover, the mitochondrial DNA content in tumor cells is lower than that in normal cells, which, together with the weakly acidic environment, prevents oxidative stress-induced cell death

Protein-bound uremic toxins (IS, pCS, PAGln) accumulate exponentially as eGFR declines below 60 mL/min/1.73 m 2 due to saturable OAT1/3-mediated tubular secretion (113, 167), with patients at eGFR 30 exhibiting 510 higher IS than those at eGFR 90reflecting clearance impairment rather than unique pathogenic mechanisms

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Gene expression of renal cells in kidney organoids, such as podocytes and tubular epithelial cells, was increased after ERT in GLA-KO human iPSC kidney organoids (Fig