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396 Moreover, demethylation treatment can disrupt protein methylation, leading to the accumulation of SAH while depleting cellular SAM, resulting in the inhibition of autophagy and apoptosis induced by endoplasmic reticulum stress in pancreatic cancer cells

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Additionally, cholesterol metabolites, particularly oxysterols, modulate LXR and SREBP2 signaling, leading to altered lipid metabolism and metabolic reprogramming that further favors tumorigenesis [6, 11]

13.1%, p =0.03) than NUCs alone, but not in mild cases ( p =0.50)

The differences that existed between the evaluated study groups were assessed by performing an analysis of variance (One-way ANOVA) and the post hoc test (Tukey test) to conduct pair-wise comparisons