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Gut barrier damage and endotoxemia: mechanisms and effects Under hyperthermic conditions, superficial blood vessels dilate to dissipate heat, leading to reduced blood flow to visceral organs (especially the intestinal mucosa) in a murine heat stress model, which in turn causes damage and apoptosis of intestinal epithelial cells, increased intestinal epithelial permeability, and impaired intestinal mucosal barrier [17]

McInnes L, Healy J, Saul N, Grossberger L

Since T cells play an essential role in controlling herpesvirus immunity, latency and reactivation 13,14,15,16,17 , T cell-inducing vaccines may provide a path towards protection from EEHV-HD

Conversely, chronic iron accumulation can promote M2-like polarization, supporting an immunosuppressive environment [100]

Dyslipidemia has been identified as a contributing factor to MGD development

Results GSH synthesis is required for the survival of adult animals To better understand the importance of GSH in adult mammals, we developed an inducible, whole-body Gclc KO mouse by breeding the Gclc f/f mouse strain 30 with the Rosa26-CreERT2 mouse strain 31