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Therefore, the biological effects of peptides on wound healing-related cells are of interest in which could also provide a theoretical basis for the application of the peptides in promoting wound healing (Figure 1)

Emerging human studies provide encouraging translational support, showing that luteolin, administered primarily as ultramicronized PEA-luteolin, reduces key inflammatory cytokines (IL-6, IL-1, TNF-), mast-cell mediators, and oxidative stress biomarkers ( Therefore, this review aims to synthesize current mechanistic, preclinical, and translational evidence on luteolin across major female reproductive disorders and to evaluate its potential as a multi-target therapeutic candidate

Abbreviations 5-HD: 5-hydroxydecanoate AMPK: AMP-activated protein kinase ETC: Electron transport chain G-6-P: Glucose-6-phosphate Glut-1: Glucose transporter 1 LPS: Lipopolysaccharide MnSOD: Manganese superoxide dismutase MRS: magnetic resonance spectrum mtDNA: Mitochondrial DNA nDNA: Nuclear DNA NO: nitric oxide NOS: nitrogen species NRF-1: Nuclear respiratory factor-1 NRF-1/2: nuclear respiratory factors 1 and 2 OXPHOS: Oxidative phosphorylation PGC-1: PRAR-coactivator-1 PMN: Polymorphonuclear neutrophil rhTFAM: Recombinant human TFAM ROS: Reactive oxygen species TFAM: Mitochondrial transcription factor A TPP: Triphenylphosphonium VDACs: Voltage dependent anion channels References Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al

View our lab testing program What is Dihexa's proposed mechanism of action at the HGF/MET receptor pathway

10.1210/clinem/dgad463 [DOI] [PMC free article] [PubMed] [Google Scholar] Thner T., Lange C., Jauckus J., Strowitzki T., Germeyer A

Arolfo, M