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In this study, high-dose WEH supplementation in NH did not affect body weight and was not associated with significant toxicity or adverse effects on the normal growth and development of the liver, spleen, and kidneys

However, none of these drugs are approved for the treatment of PFIC by the European Medicines Agency (EMA) (except for UDCA, which is approved in France for the treatment of PFIC3) [14] and their efficacy is debated [1], being often unable to avoid disease progression and listing for LT [6, 8]