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Furthermore, in the studies covering a stimulus and disease with organ-specific cytotoxicity, the significance of measuring organ-specific biomarkers greatly increases (Tajima et al., 2019

Proteins not only embody disease pathology but also flow into CSF and plasma, linking proteomics directly with fluid-based measures

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187,500,505,506 The increased activity and expression of CD38 following aging is responsible for the age-associated decrease in NAD + level and defective mitochondrial function, which is at least partially regulated by the NAD + /SIRT3 signaling pathway

Data 6 (1), 240247