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The upregulation of the expression of glutamine transporters and increased expression of GOT1/2 in the TCA cycle in KRAS-mutant tumors are promising targets for the treatment of such cancers

doi: 10.12688/f1000research 267 FenouilletEVigourouxASteinbergJGChagvardieffARetornazFGuieuRet al

The key histological abnormalities of AD include necrosis and apoptosis of VSMCs, fracture of elastic fibers, and degradation of extracellular matrix (ECM) (73).The thrombi formed within the false lumen indicates the presence of continued inflammation under the condition of atherosclerosis and chronic inflammation, and the higher risk of rupture in patients with inflammatory diseases demonstrates the importance of inflammation in AD (74)

These findings suggest a potential mechanism for the heterogeneity of treatment effect based on the TOLLIP genotype observed in PANTHER, and that NAC therapy may provide clinical benefit in a significant number of patients with IPF

528 Excess irons can promote the progression of atherosclerosis by affecting macrophages, and a balanced intracellular iron environment is crucial in alleviating atherosclerosis