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In conclusion, although the administration of AS-IV or FA alone can also undeniably improve BDL-induced liver fibrosis to a certain extent, the combined application of natural active products derived from Chinese herbal medicines is effective in inhibiting the activation of HSCs

Rolls ET, Cheng W, Du J, Wei D, Qiu J, Dai D, et al

The caffeine adds another consideration

Nssberger, L

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Indeed, ECs or transgenic mice harboring PAH-causing mutations exhibit substantially more Gln-derived carbon throughout the Krebs cycle than wild-type controls