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They are synthesized and secreted by different immune cells (like monocytes, macrophages, T cells, B cells and NK cells) and non-immune cells (like endothelial cells, epidermal cells, and fibroblasts) in response to stimuli ( Within the tumor microenvironment (TME), cytokines serve as vital signaling proteins with diverse functions, which have antineoplastic and/or tumor-promoting effects on the occurrence and progression of tumors ( Figure 1 )

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