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Cells were passaged upon reaching approximately 80% confluence

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Through the analysis of clinical data of LAC patients, the expression of PD-L1 in tumours in the TP53/KRAS comutation group was increased, and the proportion of CD8 + T cells in TME was higher, which was consistent with the clinical benefit of TP53, KRAS or TP53/KRAS-mutated cancer patients after treatment with PD-1 inhibitors 113

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Foster J.A., McVey Neufeld K.-A

To contend with the pronounced heterogeneity of GBM while simultaneously engaging multiple classes of immune effector cells, TsAbs have emerged as a promising next-generation immunotherapeutic modality

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