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The binding of S100A12 to TLR4 activates TLR4 signaling pathway, and increases the expression levels of pro-inflammatory cytokines (164, 165)

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Impact of ADH and ALDH polymorphisms on alcohol metabolism Functional polymorphisms of genes for the alcohol metabolizing enzymes ADH and ALDH2, and differences in the prevalence of the polymorphic alleles in different ethnic populations, have resulted in several studies examining racial and ethnic differences in alcohol metabolism and the influence of ADH1B, ADH1C, and ALDH2 genotypes