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Vitamin B12 treatment strongly affects the brain metabolome and transcriptome, and partially compensates for the effects of Tbx1 haploinsufficiency Given the ability of vB12 prenatal treatment to rescue diverse phenotypes caused by Tbx1 haploinsufficiency (13, 14, 15), we asked whether this occurs through metabolic mechanisms that are transcriptionally regulated by TBX1 or by rebalancing the brain metabolic profile of Tbx1 +/ mice

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However, there are some considerations to keep in mind: Potential Risk of B12 Deficiency : Some studies suggest that long-term use of certain diabetes medications, including GLP-1 receptor agonists like Ozempic, may be associated with an increased risk of vitamin B12 deficiency