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In doxorubicin-resistant human uterine sarcoma (MES-SA/Dx5), apigenin reduces intracellular glutathione (GSH) levels by inhibiting ATP-binding cassette subfamily B member 1 (ABCB1) [60], while in prostate cancer, it reverses doxorubicin resistance by down-regulating ABCB1 protein expression [61]

This is exciting as previous research found that insulin resistance may involve the emergence of an insulin-activated negative feedforward loop targeting signalling downstream of Akt