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Although, UA in plasma exerts powerful antioxidant effects, in the hydrophobic and acidic milieu and in cytoplasm of the cells UA at supra-physiological amounts acts as a pro-oxidant and promotes oxidative stress, both in soluble and crystalized forms

FOXO4-DRIs D-retro-inverso configuration provides exceptional proteolytic stability compared to equivalent L-amino acid senolytic peptides a critical property for cell-based and pre-clinical research where intracellular peptidase activity would rapidly degrade unstable L-amino acid sequences