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In some cases, the affinity optimization is aimed at increasing the affinity by at least 2-fold, at least 3-fold, at least 4-fold, at least 5-fold, at least 6-fold, at least 7-fold, at least 8-fold, at least 9-fold, at least 10-fold, at least 20-fold, at least 30-fold, at least 40-fold, at least 50-fold, at least 100-fold, at least 500-fold, or at least 1,000-fold or more as compared to the affinity of the original antibody

Researchers must comply with all applicable institutional, state, and federal regulations governing the use of research chemicals

Benhar M, Forrester MT, Hess DT, Stamler JS

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Consequently, the targeting of SLC1A5-AS/MZF1 in combination with ASCT2 inhibitor therapy may represent a viable strategy for the treatment of HCC

PMID: 11 Dionisio-SeseM