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Via regulation of p53 deacetylation and modulation of autophagy, SIRT1 is implicated in cellular response to caloric restriction and lifespan extension

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Furthermore, SYNCRIP depletion resulted in a marked decrease in intracellular NAD + levels, a crucial cofactor required for the enzymatic activity of the NAD + -dependent deacetylase SIRT1 (Figure S4F-H) [27]