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PubMed PMID: 23163594

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doi: 10.1007/s00018-022-04389-w 138 BattisKXiangWWinklerJ

T.HazarikaO.VutskitsL.SallJ

(2015) found a drop in GSH levels and Nernst potential (Eh) (indicating oxidative stress), an increase in 4-hydroxynonenal (4-HNE), and a decline in ovarian follicles in Gclm null female mice

An important early example investigated the effect of both knockout and transgenic uricase in mice receiving intracerebral 6-hydroxydopamine administration, which leads to dopaminergic neurodegeneration 33