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Ladd Prosser, at the University of Illinois Champaign-Urbana, taught his students, including me, that acquisition of a total understanding of mechanisms at lower tiers of a central neural hierarchy does not enable prediction of the kinds of behavior that will emerge at the next higher tier or for that matter at levels of whole animal behavior

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A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]

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